Reza’s work is published in Nature Communications

Reza's work on the regulation of leader cell formation via Notch1-Dll4 signaling is accepted to Nature Communications. In this work, Reza, along with Sun Jian and Shue, demonstrated the formation of leader cell is dynamically regulated by intercellular stress and Notch1-Dll4 lateral inhibition. Great job everyone!   


SBL will complete in the NIH single cell challenge

SBL is selected as one of the 16 finalists in the NIH's single cell analysis program "follow that cell" challenge. Phase 2 begins on March 17, 2015 and is open only to the 16 finalists. During Phase 2, Reduction to Practice, finalists will generate proof-of-concept data related to their Phase 1 entries. These submissions are due March 30, 2017. Winners of Phase 2 will be awarded prize money from a pool of $400,000, to be announced July 31, 2017.


3D tumor tissue constructs

Paul won the Honor College undergraduate research grant to develop novel 3D tumor tissues for deciphering the mechanoregulation of cancer invasion. In this project, Paul will apply advanced biomanufacturing techniques to create arbitrary 3D tumor tissue constructs. The 3D tumor tissues will be applied to elucidate the factors regulating collective migration and invasion of cancer cells. Congrats Paul and thanks for the excellent mentor Zach. Great job everyone!


Keynote speaker in Optofluidics 2015

Dr. Wong will be a keynote speaker in Optofluidics 2015, Taipei. The aim of Optofluidics2015 conference is to provide a forum to promote scientific exchange and to foster closer networks and collaborative ties between leading international optics and micro/nanofluidics researchers across various disciplines. The scope of Optofluidics 2015 is deliberately broad and interdisciplinary, encompassing the latest advances and the most innovative developments in micro/nanoscale science and technology. The abstract submission deadline is April 10, 2015. See you in Taipei!


Reza and Shue’s work is selected as a JALA10

Reza and Shue's single cell biosensor is selected as one of the JALA10- a top 10 technological breakthrough innovation in 2015. Reza and Shue demonstrate single-cell gene expression analysis in the native tissue environment using a gold nanorod-locked nucleic acid probe (GNR-LNA). The technology opens new opportunities in studying tissue morphogenesis and elucidating cancer heterogeneity in native tumor microenvironments. Great job, congratulations everyone!


IEEE Transactions on Nanotechnology

Dr. Wong is appointed as an associate editor for the The IEEE Transactions on Nanotechnology (TNANO) starting Jan 2015. TNANO publishes novel and important results in engineering at the nanoscale. It focuses on nanoscale devices, systems, materials and applications, and on their underlying science. It is an interdisciplinary journal that covers all areas of nanotechnology.


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Systematic Bioengineering Laboratory

The systematic bioengineering laboratory develops novel technologies and approaches to decipher and control complex biological systems toward regenerating medicine, biomanufacturing and clinical diagnostic applications.





Featured Publications

R. Riahi, J. Sun, S. Wang, M. Long, D. D. Zhang, and P. K. Wong, “Notch1-Dll4 signaling and mechanical force regulate leader cell formation during collective cell migration” Nature Communications 6, 6556, 2015. Link


Z. Dean, R. Riahi, P. K. Wong, “Spatiotemporal dynamics of microRNA during epithelial collective cell migration” Biomaterials 37, 156-163, 2015. Link


R. Riahi, S. Wang, M. Long, N. Li, P.-Y. Chiou, D. D. Zhang, and P. K. Wong, “Mapping Photothermally Induced Gene Expression in Living Cells and Tissues by Nanorod-Locked Nucleic Acid Complexes” ACS Nano 8, 3597-3605, 2014.  Link


T. Liu, M. L. Y. Sin, J. D. Pyne, V. Gau, J. C. Liao, and P. K. Wong, “Electrokinetic Stringency Control in Self-Assembled Monolayer-based Biosensors for Multiplex Urinary Tract Infection Diagnosis”, Nanomedicine: Nanotechnology, Biology, and Medicine 10, 159-166, 2014. Link


Y. Lu, J. Gao, D. D. Zhang, V. Gau, J. C. Liao, and P. K. Wong, “Single cell antimicrobial susceptibility testing by confined microchannels and electrokinetic loading”, Analytical Chemistry 85, 3971-3976, 2013. Link


M. L. Y. Sin, T. Liu, J. D. Pyne, V. Gau, J. C. Liao, and P. K. Wong, “In situ electrokinetic enhancement for self-assembled monolayer based electrochemical biosensing”, Analytical Chemistry 84, 2702-2707, 2012. Link


M. Junkin, S. L. Leung, S. Whitman, C. C. Gregorio, and P. K. Wong, "Cellular Self-Organization via Autocatalytic Alignment Feedback", Journal of Cell Science 124, 4213-4220, 2011.  Link


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