News Reza’s work is published
in Nature Communications Reza's work on the regulation of leader cell formation via
Notch1-Dll4 signaling is accepted to Nature Communications. In this work,
Reza, along with Sun Jian and Shue, demonstrated the formation of leader cell
is dynamically regulated by intercellular stress and Notch1-Dll4 lateral
inhibition. Great job everyone! SBL will complete in the NIH
single cell challenge SBL is selected as one of the 16 finalists in the NIH's single
cell analysis program "follow that cell" challenge. Phase 2 begins
on March 17, 2015 and is open only to the 16 finalists. During Phase 2,
Reduction to Practice, finalists will generate proof-of-concept data related
to their Phase 1 entries. These submissions are due March 30, 2017. Winners
of Phase 2 will be awarded prize money from a pool of $400,000, to be
announced July 31, 2017. 3D tumor tissue constructs Paul won the Honor College undergraduate research grant to
develop novel 3D tumor tissues for deciphering the mechanoregulation of
cancer invasion. In this project, Paul will apply advanced biomanufacturing
techniques to create arbitrary 3D tumor tissue constructs. The 3D tumor
tissues will be applied to elucidate the factors regulating collective
migration and invasion of cancer cells. Congrats Paul and thanks for the
excellent mentor Zach. Great job everyone! Keynote speaker in Optofluidics 2015 Dr. Wong will be a keynote speaker in Optofluidics
2015, Taipei. The aim of Optofluidics2015 conference is to provide a forum to
promote scientific exchange and to foster closer networks and collaborative
ties between leading international optics and micro/nanofluidics
researchers across various disciplines. The scope of Optofluidics
2015 is deliberately broad and interdisciplinary, encompassing the latest
advances and the most innovative developments in micro/nanoscale science and
technology. The abstract submission deadline is April 10, 2015. See you in
Taipei! Reza and Shue’s work is selected as a JALA10 Reza and Shue's
single cell biosensor is selected as one of the JALA10- a top 10
technological breakthrough innovation in 2015. Reza and Shue demonstrate
single-cell gene expression analysis in the native tissue environment using a
gold nanorod-locked nucleic acid probe (GNR-LNA). The technology opens new
opportunities in studying tissue morphogenesis and elucidating cancer
heterogeneity in native tumor microenvironments. Great job, congratulations
everyone! IEEE Transactions on Nanotechnology Dr. Wong is appointed as an associate
editor for the The IEEE Transactions on
Nanotechnology (TNANO) starting Jan 2015. TNANO publishes novel and important
results in engineering at the nanoscale. It focuses on nanoscale devices,
systems, materials and applications, and on their underlying science. It is
an interdisciplinary journal that covers all areas of nanotechnology. |
Systematic
Bioengineering Laboratory The
systematic bioengineering laboratory develops novel technologies and
approaches to decipher and control complex biological systems toward
regenerating medicine, biomanufacturing and clinical diagnostic applications. |
Featured Publications R. Riahi, J. Sun, S. Wang, M. Long, D.
D. Zhang, and P. K. Wong, “Notch1-Dll4 signaling and mechanical force
regulate leader cell formation during collective cell migration” Nature Communications 6, 6556, 2015. Link Z. Dean, R. Riahi, P. K. Wong,
“Spatiotemporal dynamics of microRNA during epithelial collective cell
migration” Biomaterials 37,
156-163, 2015. Link R. Riahi, S. Wang, M. Long, N. Li,
P.-Y. Chiou, D. D. Zhang, and P. K. Wong, “Mapping Photothermally Induced
Gene Expression in Living Cells and Tissues by Nanorod-Locked Nucleic Acid
Complexes” ACS Nano 8, 3597-3605,
2014. Link T. Liu, M. L. Y. Sin, J. D. Pyne, V.
Gau, J. C. Liao, and P. K. Wong, “Electrokinetic Stringency Control in
Self-Assembled Monolayer-based Biosensors for Multiplex Urinary Tract
Infection Diagnosis”, Nanomedicine:
Nanotechnology, Biology, and Medicine 10, 159-166, 2014. Link Y. Lu, J. Gao, D. D. Zhang, V. Gau, J. C. Liao, and P. K. Wong,
“Single cell antimicrobial susceptibility testing by confined microchannels
and electrokinetic loading”, Analytical
Chemistry 85, 3971-3976, 2013. Link M. L. Y. Sin, T. Liu, J. D. Pyne, V.
Gau, J. C. Liao, and P. K. Wong, “In situ electrokinetic enhancement for
self-assembled monolayer based electrochemical biosensing”, Analytical Chemistry 84, 2702-2707,
2012. Link M. Junkin, S. L. Leung, S. Whitman, C. C. Gregorio, and P. K.
Wong, "Cellular Self-Organization via Autocatalytic Alignment
Feedback", Journal of Cell Science
124, 4213-4220, 2011. Link |
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