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Archived Journal Publications

1.        Tao Jiang, Bryan Harder, Montserrat Rojo de la Vega, Pak Wong, Eli Chapman, Donna Zhang, “p62 links autophagy and Nrf2 signaling”, Free Radical Biology & Medicine (in press).

2.        Y. Lu, T. Liu, A. C. Lamanda, M. L. Y. Sin, V. Gau, J. C. Liao, and P. K. Wong, “AC Electrokinetics of Physiological Fluids for Biomedical Applications” Journal of Laboratory Automation (in press). Link

3.        T. Wu, B. G. Harder, P. K. Wong, J. E. Lang, and D. D. Zhang, “Oxidative Stress, Mammospheres and Nrf2 – New Implication for Breast Cancer Therapy” Molecular Carcinogenesis (in press). Link

4.        T. Shen, T. Jiang, M. Long, J. Chen, D. Ren, P. K. Wong, E. Chapman, B. Zhou, and D. D. Zhang, “ A curcumin derivative that inhibits vinyl carbamate-induced lung carcinogenesis via activation of the Nrf2 protective response”, Antioxidants and Redox Signaling (in press). Link

5.        R. Riahi, J. Sun, S. Wang, M. Long, D. D. Zhang, and P. K. Wong, “ Notch1-Dll4 signaling and mechanical force regulate leader cell formation during collective cell migration” Nature Communications 6, 6556, 2015.  Link  PDF  SI

6.        K. Mach, R. Mohan, S. Patel, P. K. Wong, M. Hsieh, J. C. Liao, “Development of a biosensor-based rapid urine test for detection of urogenital schistosomiasis”, PLOS Neglected Tropical Diseases e0003845, 2015. Link

7.        J. Sun, Y. Xiao, S. Wang, M. J. Slepian, and P. K. Wong, “Advances in techniques for probing mechanoregulation of tissue morphogenesis”  Journal of Laboratory Automation 20, 127, 2015. Link PDF

8.        Z. Dean, R. Riahi, P. K. Wong, “Spatiotemporal dynamics of microRNA during epithelial collective cell migration” Biomaterials 37, 156-163, 2015. PDF

9.        S. Tao, S. Wang, S. J. Moghaddam, A. Ooi and E. Chapman, P. K. Wong and D. D. Zhang, “Oncogenic KRAS confers chemoresistance by transcriptional upregulation of NRF2 via the TPA Response Element” Cancer Research 74, 7430-7441, 2014.  PDF

10.      T. Wu, F. Zhao, B. Gao, C. Tan, N. Yagishita, T. Nakajima, P. K. Wong, E. Chapman, D. Fang, and D. D. Zhang. “Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis” Genes & Development 28, 708-722, 2014. PDF

11.      K.-H. Nam, N. Jamilpour, E. Mfoumou, F.-Y. Wang, D. D. Zhang, and P. K. Wong, “Probing Mechanoregulation of Neuronal Differentiation by Plasma Lithography Patterned Elastomeric Substrates” Scientific Reports 4, 6965, 2014. PDF

12.      R. Riahi, S. Wang, M. Long, N. Li, P.-Y. Chiou, D. D. Zhang, and P. K. Wong, “Mapping Photothermally Induced Gene Expression in Living Cells and Tissues by Nanorod-Locked Nucleic Acid Complexes” ACS Nano 8, 3597-3605, 2014. PDF

13.      T. Liu, Y Lu, V. Gau, J. C. Liao, and P. K. Wong, “Rapid antimicrobial susceptibility testing with electrokinetics enhanced biosensors for diagnosis of acute bacterial infections” Annals of Biomedical Engineering 42, 2314-2321, 2014. PDF

14.      J. Sun, N. Jamilpour, F.-Y. Wang, and P. K. Wong, “Geometric Control of Capillary Architecture via Cell-Matrix Mechanical Interactions”, Biomaterials 35, 3273-3280, 2014. PDF

15.      T. Liu, M. L. Y. Sin, J. D. Pyne, V. Gau, J. C. Liao, and P. K. Wong, “Electrokinetic Stringency Control in Self-Assembled Monolayer-based Biosensors for Multiplex Urinary Tract Infection Diagnosis”, Nanomedicine: Nanotechnology, Biology, and Medicine 10, 159-166, 2014. PDF   

16.      M. L. Y. Sin, K. E. Mach, P. K. Wong, and J. C. Liao, “Advances and challenges in biosensor-based diagnosis of infectious diseases”, Expert Review of Molecular Diagnostics 2, 225-244, 2014. PDF

17.      R. Riahi, M. Long, Y. Yang, Z Dean, D. D. Zhang, M. J. Slepian, and Pak Kin Wong, “Single Cell Gene Expression Analysis in Injury-Induced Collective Cell Migration”, Integrative Biology 6, 192-202, 2014. PDF

18.      M. W. Kadlec, D. You, J. C. Liao, and P. K. Wong, “A cell phone-based microphotometric system for rapid antimicrobial susceptibility testing”, Journal of Laboratory Automation 19, 258-266, 2014.  PDF

19.      R. Riahi Y. L. Yang, H. Kim, L. Jiang, P. K. Wong, and Y. Zohar. “A microfluidic model for organ-specific extravasation of circulating tumor cells”, Biomicrofluidics 8, 024103, 2014. PDF

20.      S. Tao, Y. Zheng, A. Lau, M. C. Jaramilo, B. T. Chau, C. R. Lantz, P. K. Wong, G. Wondrak, and D. D. Zhang, “Tanshinone l activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo”, Antioxidants & Redox Signaling 19, 1647-1661, 2013. PDF 

21.      M. L. Y. Sin, V. Gau, J. C. Liao, and P. K. Wong, “A Universal Electrode Approach for Automated Electrochemical Molecular Analyses”, IEEE/ASME Journal of Microelectromechanical Systems 22, 1126-1132, 2013. PDF  

22.      R. Riahi, Z. Dean, T.-H. Wu, M. A. Teitell, P.-Y. Chiou, D. D. Zhang, and P. K.  Wong, “Detection of mRNA in living cells by double-stranded locked nucleic acid probes”, Analyst 138, 4777-4785, 2013. PDF  

23.      M. Ouyang, R. Mohan, Y. Lu, T. Liu, K. E. Mach, M. L. Y. Sin, M. McComb, J. Joshi, V. Gau, P. K. Wong, J. C. Liao, “AC Electrokinetics Facilitated Biosensor Cassette for Rapid Pathogen Identification”, Analyst 138, 3660-3666, 2013. PDF

24.      Y. Lu, J. Gao, D. D. Zhang, V. Gau, J. C. Liao, and P. K. Wong, “Single cell antimicrobial susceptibility testing by confined microchannels and electrokinetic loading”, Analytical Chemistry 85, 3971-3976, 2013. PDF

25.      M. Junkin, Yi Lu, J. Long, P. Deymier, J. Hoying, and P. K. Wong, "Mechanically Induced Intercellular Calcium Communication in Confined Endothelial Structures", Biomaterials 34, 2049-2056, 2013. PDF

26.      F.-Y. Wang and P. K. Wong, “Intelligent Systems and Technology for Integrative and Predictive Medicine: An ACP Approach”, ACM Transactions on Intelligent Systems and Technology 4, No. 32, 2013. PDF

27.      M. L. Y. Sin, V. Gau, J. C. Liao, and P. K. Wong, “A Universal Electrode Approach for Molecular Diagnostics”, IEEE Nanotechnology Magazine 7, 31-37, 2013. PDF

28.      J. Long*, M. Junkin*, P. K. Wong, J. Hoying, and P. Deymier, “Calcium Wave Propagation in Networks of Endothelial Cells: Model-based Theoretical and Experimental Study”, PLoS Computational Biology 8, e1002847, 2012. (* equal contribution) PDF

29.      J. Gao, R. Riahi, M. L. Y. Sin, S. Zhang, and P. K. Wong, “Electrokinetic Focusing and Separation of Mammalian Cells in Conductive Biological Fluids”, Analyst 137, 5215-5221, 2012. (This paper is featured in the inside cover.) PDF

30.      M. L. Y. Sin, T. Liu, J. D. Pyne, V. Gau, J. C. Liao, and P. K. Wong, “In situ electrokinetic enhancement for self-assembled monolayer based electrochemical biosensing”, Analytical Chemistry 84, 2702-2707, 2012. PDF

31.      R. Riahi, Y. Yang, D. D. Zhang, and P. K. Wong, "Advances in Wound Healing Assays for Probing Collective Cell Migration" Journal of Association for Laboratory Automation 17, 59-65, 2012. PDF

32.      M. Junkin, S. L. Leung, S. Whitman, C. C. Gregorio, and P. K. Wong, "Cellular Self-Organization via Autocatalytic Alignment Feedback", Journal of Cell Science 124, 4213-4220, 2011. (This paper is featured as the cover article and is highlight by the editor) PDF HIGHLIGHT

33.      R. Riahi, K. Mach, R. Mohan, J. C. Liao, and P. K. Wong, "Molecular Detection of Bacterial Pathogens using Particle Enhanced Double-Stranded DNA Probes", Analytical Chemistry 83, 6349-6354, 2011. PDF

34.      M. Junkin and P. K. Wong, "Probing Cell Migration in Confined Environments by Plasma Lithography", Biomaterials 32, 1848-1855, 2011. PDF

35.      K. E. Mach, P. K. Wong, and J. C. Liao, "Biosensor Diagnosis of Urinary Tract Infections: A Path to Better Treatment?", Trends in Pharmacological Sciences 32, 330-336, 2011. PDF

36.      J. Gao, M. L. Y. Sin, T. Liu, V. Gau, J. C. Liao, and P. K. Wong, " Hybrid Electrokinetic Manipulation in High-Conductivity Media", Lab on a Chip 11, 1770-1775, 2011. PDF

37.      R. Mohan, K. E. Mach, M. Bercovici, P. K. Wong, and J. C. Liao, "Clinical validation of integrated nucleic acid and protein detection on an electrochemical biosensor array for urinary tract infection diagnosis", PLoS ONE 6, e26846, 2011. PDF

38.      Y. Yang, J. Volmering, M. Junkin, and P. K. Wong, "Comparative Assembly of Colloidal Quantum Dots on Surface Templates Patterned by Plasma Lithography, Soft Matter 7, 10085-10090, 2011. PDF

39.      H. Zheng, S. A. Whitman, W. Wu, G. Wondrak, P. K. Wong, D. Fang, and D. D. Zhang, "Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy", Diabetes 60, 3055-3066, 2011. PDF

40.      K. E. Mach, R. Mohan, E. J. Baron, M.-C. Shih, V. Gau, P. K. Wong, and J. C. Liao, “A Versatile Biosensor Platform for Rapid Antimicrobial Susceptibility Testing Directly from Clinical Samples”, Journal of Urology 185, 148-153. 2011. PDF

41.      M. Junkin, S. L. Leung, Y. Yang, Y. Lu, J. Volmering, and P. K. Wong, " Plasma lithography surface patterning for creation of cell networks", Journal of Visualized Experiments 52, 2011.  Link

42.      M. L. Y. Sin, J. Gao, J. C. Liao and P. K. Wong, "System Integration - A Major Step Toward Lab on a Chip", Journal of Biological Engineering 5:6, 2011.  PDF

43.      S. Choi, M. Goryll, M. L. Y. Sin, P. K. Wong, and J. Chae, “Microfluidic-Based Biosensor toward Point-of-care Detection of Nucleic Acids and Proteins”, Microfluidics and Nanofluidics 10, 231-247, 2011. PDF

44.      C. H. Chen, V. Gau, D. D. Zhang, J. C. Liao, Fei-Yue Wang, and P. K. Wong, “Statistical Metamodeling for Revealing Synergistic Antimicrobial Interactions”, PLoS ONE 5, e15472, 2010. PDF

45.      Chia Hsiang Chen, Yi Lu, Mandy L. Y. Sin, Kathleen E. Mach, Donna D. Zhang, Vincent Gau, Joseph C. Liao, and Pak Kin Wong, “Antimicrobial Susceptibility Testing Using High Surface-to-Volume Ratio Microchannels”, Analytical Chemistry 8, 1012-1019, 2010. PDF

46.      M. L. Y. Sin, V. Gau, J. C. Liao, and P. K. Wong, “Electrothermal Fluid Manipulation of High-Conductivity Samples for Laboratory Automation Applications”, Journal of Association for Laboratory Automation 15, 426-432, 2010. PDF

47.      Y. Pan, G. A. Sonn, M. L. Y. Sin, K. E. Mach, M.-C. Shih, V. Gau, P. K. Wong, and J. C. Liao, “Electrochemical Immunosensor Detection of Urinary Lactoferrin in Clinical Samples for Urinary Tract Infection Diagnosis”, Biosensors and Bioelectronics 26, 649-654, 2010. PDF

48.      May L. Chiu, Walson Lawi, Steven T. Snyder, Pak Kin Wong, Joseph Liao, and Vincent Gau, “Matrix Effects – A Challenge Toward Automation of Molecular Analysis”, Journal of the Association for Laboratory Automation 15, 233-242, 2010.  PDF

49.      N. Li, and P. K. Wong, “Transfection of Molecular Beacons in Microchannels for Single Cell Gene Expression Analysis”, Bioanalysis 2, 1689-1699, 2010. PDF

50.      Tza-Huei Wang and Pak Kin Wong, “Transforming Microfluidics into Laboratory Automation”, Journal of the Association for Laboratory Automation, 15, A15-16, 2010. PDF

51.      Deok-Ho Kim, Pak Kin Wong, Jungyul Park, Andre Levchenko, and Yu Sun, "Microengineered Platforms for Cell Mechanobiology," Annual Review of Biomedical Engineering 11, 203-233, 2009. PDF

52.      Michael Junkin, Jennifer Watson, Jonathan P. Vande Geest, and Pak Kin Wong, “Template-Guided Self-Assembly of Colloidal Quantum Dots using Plasma Lithography”, Advanced Materials 21, 1247-1251, 2009. PDF

53.      Mandy L. Y. Sin, Vincent Gau, Joseph C. Liao, David A. Haake, and Pak Kin Wong, “Active Manipulation of Quantum Dots Using AC Electrokinetics", Journal of Physical Chemistry C 113, 6561-6565, 2009. PDF

54.      Fei Zhao, Tongde Wu, Alexandria Lau, Tao Jiang, Zheping Huang, Xiao-Jun Wang, Weimin Chen, Pak Kin Wong, Donna D. Zhang, “Nrf2 promotes neuronal cell differentiation”, Free Radical Biology and Medicine 47, 867-879, 2009. PDF

55.      Walson Lawi, Chris Wiita, Steven T. Snyder, Fang Wei, avid Wong, Pak Kin Wong, Joseph C. Liao, David Haake, Vincent Gau, “A Microfluidic Cartridge System for Multiplexed Clinical Analysis”, Journal of the Association for Laboratory Automation 14, 407-412, 2009. PDF

56.      Joseph Keyes, Michael Junkin, Pak Kin Wong, Jonathan P. Vande Geest, “Computational Simulation of a Magnetic Microactuator for Tissue Engineering Applications”, Biomedical Microdevices 11, 1259-1267, 2009. PDF

57.      Vinay Gidwani, Reza Riahi, Donna D. Zhang, and Pak Kin Wong, “Hybridization Kinetics of Double-Stranded DNA Probes for Rapid Molecular Analysis”, Analyst 134, 1675-1681, 2009.  (This paper is featured as the cover article) PDF

58.      Jungkyu Kim., Michael Junkin, Deok-Ho Kim, Seugnlee Kwon, Young Shik Shin, Pak Kin Wong, and Bruce K. Gale, “Applications, Techniques, and Microfluidic Interfacing for Nanoscale Biosensing”, Microfluidics and Nanofluidics 7, 149-167, 2009. PDF

59.      Mandy L. Y. Sin, Yusuke Shimabukuro, and Pak Kin Wong, “Hybrid Electrokinetics for Separation, Mixing, and Concentration of Colloidal Particles", Nanotechnology 20 165701, 2009. PDF

60.      Joseph C. Liao, and Pak Kin Wong, “Nanotechnology and Prostate Cancer”, AUA News 13, 5-6, 2008 (invited article). PDF

61.      Pak Kin Wong, Fu Yu, Arash Shahangian, Genhong Cheng, Ren Sun, and Chih-Ming Ho, "Closed-Loop Control of Cellular Functions using a Stochastic Search Algorithm," Proceedings of the National Academy of Sciences 105, 5105-5110, 2008. (This paper is featured in numerous news highlights including Eureka, Science Daily) PDF

62.      Alexandria Lau, Nicole F. Villeneuve, Zheng Sun, Pak Kin Wong, Donna D. Zhang, “Dual roles of Nrf2 in cancer”, Pharmacological Research 58, 262-270, 2008. PDF

63.      Joseph Keyes, Michael Junkin, Joseph Cappello, Xiaoyi Wu, and Pak Kin Wong, “Evaporation-induced assembly of biomimetic polypeptides,Appl. Phys. Lett. 93, 023120, 2008. (This paper is selected for publication in the Virtual Journal of Nanoscale Science & Technology and in the Virtual Journal of Biological Physics Research) PDF

64.      Daniel Meserve, Zhaohui Wang, Donna D. Zhang, and Pak Kin Wong, "A double-stranded molecular probe for homogeneous nucleic acid analysis," Analyst 133, 1313-1319, 2008. (This paper is selected for publication in the RSC’s Chemical Biology Research Article Virtual Journal) PDF

65.      Xiao-Jun Wang, Zheng Sun, Nicole F. Villeneuve, Shirley Zhang, Fei Zhao, Yanjie Li, Weimin Chen, Xiaofang Yi, Wenxin Zheng, Georg T. Wondrak, Pak Kin Wong, and Donna D. Zhang, "Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2," Carcinogenesis 29, 1235-1243, 2008. PDF

66.      Zhaohui Wang, Vinay Gidwani, Donna D. Zhang and Pin Kin Wong, “Separation-free detection of nuclear factor kappa B with double-stranded molecular probes”, Analyst 133, 998-1000, 2008. (Cover article) (This paper is selected for publication in the RSC’s Chemical Biology Research Article Virtual Journal) PDF

67.      Yu Du, Nicole F. Villeneuve, Xiao-Jun Wang, Zheng Sun, Weimin Chen, Jixue Li, Hongxiang Lou, Pak Kin Wong, and Donna D. Zhang, "Oridonin confers protection against arsenic induced toxicity through activation of the Nrf2-mediated defensive response," Environmental Health Perspectives 116, 1154-1161, 2008.  PDF

68.      Zhaohui Wang, Vinay Gidwani, Zheng Sun, D. D. Zhang, and P. K. Wong, "Development of a molecular assay for rapid screening of chemopreventive compounds targeting Nrf2," Journal of the Association for Laboratory Automation 13, 243-248, 2008. PDF

69.      Pak Kin Wong and Dean Ho, "Emergent Diagnostic and Therapeutic Platforms for Nanoengineered Medicine," IEEE Nanotechnology Magazine 2, 9-13, 2008. PDF

70.      Pak Kin Wong, Winny Tan, Chih-Ming Ho, "Cell Relaxation after Electrodeformation: Effect of Latrunculin A on Actin Cytoskeleton", Journal of Biomechanics 38, 529-535, 2005. PDF

71.      Tza-Huei Wang, Yahui Peng, Chunyang Zhang, Pak Kin Wong, Chih-Ming Ho, "Single-Molecule Tracing on a Fluidic Microchip for Quantitative Detection of Low-Abundance Nucleic Acids", Journal of American Chemical Society 127, 5354-5359, 2005.   (Highlighted in Nanozone news in Nature, April 28, 2005) PDF

72.      Pak Kin Wong, Che-Yang Chan, Tza-Huei Wang and Chih-Ming Ho "Electrokinetic Bioprocessor for Concentrating Cells and Molecules", Analytical Chemistry 76, 6908-6914, 2004.  (This work has been highlighted in NIH NIDCR website) PDF

73.      Pak Kin Wong, Tza-Huei Wang, Joanne H. Deval, Chih-Ming Ho, "Electrokinetics in Micro Devices for Biotechnology Applications", IEEE/ASME Transactions on Mechatronics 9, 366-376, 2004. PDF

74.      Pak Kin Wong, Umberto Ulmanella and Chih-Ming Ho, "Fabrication of Microsurgical Tools for Single Cell Intracytoplasmic Injection", Journal of Microelectromechanical System 6, 940-946, 2004. PDF

75.      Tzung K. Hsiai, Sung K. Cho, Pak K. Wong, Michael H. Ing, Adler Salazar, Susan Hama, Mohamad Navab, Linda L. Demer, Chih-Ming Ho, "Micro Sensors: Linking Real-Time Oscillatory Shear Stress with Vascular Inflammatory Responses", Annals of Biomedical Engineering 32, 189-201, 2004. PDF

76.      Pak Kin Wong, Yi-Kuen Lee, Chih-Ming Ho, "Deformation of DNA Molecules by Hydrodynamic Focusing", Journal of Fluid Mechanics 497, 55-65, 2003. PDF

77.      Tzung K. Hsiai, Sung K. Cho, Pak K. Wong, Michael Ing, Adler Salazar, Alex Sevanian, Mohamad Navab, Linda L. Demer, Chih-Ming Ho, "Monocyte Recruitment to Endothelial Cells in Response to Oscillatory Shear Stress", Federation of American Societies for Experimental Biology Journal 17, 1648-1657, 2003. PDF

78.      Tzung K. Hsiai, Michael Ing, Juliana Hwang, Adler Salazar, Sung K. Cho, Pak Wong, Chih-Ming Ho, Mohamad Navab, "Endothelial Cells: The Living Sensors and Actuators", International Journal of Nonlinear Sciences and Numerical Simulation 3, 169-172, 2002. PDF



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How to write a paper

“Is a picture worth 1,000 words?”, by Julio M. Ottino.

“How to avoid the reviewer’s axe: One editor’s view”, by Stephen D. Senturia.

“Whitesides’ group: writing a paper”, by George M. Whitesides.